Navigation

Article

EFFECT OF ADAPTOGENS OF PLANT AND ANIMAL ORIGIN AND PHYSICAL ACTIVITY ON THE BODY (0.36 Mb, pdf) Read
Authors:
Khabibullin Ruzel Mullakhmetovich
Mironova Irina Valerievna
Khabibullin Ilmir Mullakhmetovich
Yagafarov Ruzil Gilemyanovich
Akhmadullina Elmira Timerbulatovna
Kadirov Nazgat Nazirovich
Pegov Valentin Alekseevich
Annotation:

The purpose of the research is to normalize carbohydrate metabolism in the mice bodies using adaptogens of various origins. 

Methods and organization of the research. For the experiment, 60 mice were selected, which were divided into 3 groups, 20 mice each. They were given different amounts of adaptogens at different periods of their lives. For all animals participating in the experiment, a swimming load was created according to the method of Porsalt. At the end of the experiment, blood samples were taken from mice of all experimental groups for morphological analysis, and the liver was subjected to histochemical studies for the presence of glycogen according to McManus.

Research results. It was found that at the beginning of the experiment in the blood serum of animals, the glucose content changed slightly, and by the end of the experiment, an increase in its level was noted in all groups. A weaker histochemical reaction to glycogen was found in hepatocytes of the liver of the control group of animals, and in the liver of mice of the experimental groups, the reaction to glycogen was more intense.

Conclusion. Thus, the weakest histochemical reaction to glycogen is found in liver hepatocytes of the control group of animals. A higher intensive histochemical reaction to glycogen is manifested in the liver of mice of the experimental groups. This is especially observed in those animals that received preparations of Leuzea safflower and pantocrine tincture.

Bibliography:
  • Armstrong, N. Muscle metabolism changes with age and growing up: how they are associated with sports performance of young people / N. Armstrong, A. Barker, A. McManus // Br J Sports Med. – 2015. No. 49 (13). – S. 860-864.
  • Coffey, V.G. The molecular bases of training adaptation / V.G. Coffey, J.A. Hawley // Sport. Med. – 2007. – Vol. 37, № 9. – P. 737-763.
  • Eun Young Kim Cardioprotective effects of aqueous Schizandrachinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: Effects on serum lipid profiles and blood pressure / Eun Young Kim, In-HeeBaek, Mee Ra Rhyu // Journal of Ethnopharmacology. – Volume 134 (Issue 3, 12 April 2011) – P. 668-675.
  • Huang C.J., Webb H.E., Zurdos M., Acevedo E. Cardiovascular reactivity, stress and physical acti­vity / - DOI: 10.3389 / fphys.2013.00314. // Front Physiol. – 2013 – Tt. 7 (4). – S. 314-318
  • Huang, L. Acanthopanaxsenticosus: review of botany, chemistry and pharmacology / L. Huang, H. Zhao, B. Huang, C. Zheng, W. Peng, L. Qin // Pharmazie. – 2011. –V. 66, N 2. – Pp. 83-97.
  • Khabibullin R. Morphogenesis of the internal organs of mice using adaptogens and physical loads / RM. Khabibullin, I. Mironova, M. A. Derkho, V. K. Strizhikov, S. Strizhikova, A. Denisenko // In the collection: IOP Conference Series: Earth and Environmental Science. 2020. S. 012053.
  • Khabibullin R.M. Morphofunctional changes in the kidneys of mice with the use of adaptogens against the background of physical exertion / R.M. Khabibullin, I. Mironova, M. A. Derkho, V. K. Strizhikov, S. Strizhikova, J. Coassi // In the collection: IOP Conference Series: Earth and Environmental Science. 2020. S. 012052.
  • Kimura, Y. Effects of various Eleutherococcussenticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice / Y. Kimura, M. Sumiyoshi // J. Ethnopharmacol. – 2004. – V. 95, № 2-3. – Pp. 447-453.
  • Lawlor, D.A. The effectiveness of exercise as a treatment for depression: a systematic review and meta-regression analysis of randomized controlled trials/ D.A. Lawlor, S. Hopker // BMJ. – 2001 .– T. 322. – P. 763.
  • Mironova I.V. Morphological changes in the muscle tissue of mice with the use of adaptogens / I.V. Mironova, R. Khabibullin, M. A. Derkho, S. Yu. Kontsevaya, S. Strizhikova, E. Ovchinnikova // In the collection: Conference Series IOP: Science of the Earth and the Environment. 2020. S. 012083.
  • Mohan, R. Biochemistry of muscle activity and physical training / R. Mohan, M. Glesson, P.L. Greenhuff. – Kiev: Olympic Literature, 2001. – 295 p.
  • Nicolaidis, M.J. The effect of muscle-damaging exercise on blood and skeletal muscle oxidative stress: magnitude and time-course considerations / M.J. Nicolaidis, A.Z. Jamurtas, V. Paschalis // Sports Med. – 2008. – Vol. 38, № 7. – P. 579-606.
  • Porsolt, R.D. Behavioral despair in mice: A primary screening test for antidepressants / R.D. Porsolt, A. Bertin // Arch. Int. Pharmacodyn. – 1977. – Vol. 229.
  • Testa, B. The biochemistry of drug metabolism – an introduction: part 1. Principles and overview / B. Testa, S. Krämer. – Chem Biodivers: journal. – 2006. – Vol. 3, no. 10. – P. 1053-1101.