Influence physical activities on near-limit of free radical oxidation and reactivity microvascular in myocardium (0.29 Mb, pdf) Read
Сагидова Светлана Александровна
Кандидат биологических наук, доцент кафедры адаптивной физической культуры и безопасности жизнедеятельности
Educational organization: ФГБОУ ВО «Поволжская государственная академия физической культуры, спорта и туризма»

The experiment evaluated the activity of antioxidant defense system (AOS) and lipid peroxidation (LPO), and morpho-functional vascular changes in the myocardium of the left ventricle of the heart under the influence of near-limit and limit physical activity. It was found that in the early days (1–5 hours) exercise accompanied by increased lipid peroxidation processes in the myocardium occurs reactive hyperemia. Adapting to swimming stress (15–30 days) leads to an increase in the antioxidant defense system capabilities, at high reactance of microvessels in the left ventricle of the heart.

  1. Gilen S. Cardiovascular effects of exercise training molecular mechanisms / S. Gilen, G.G. Schuler, V. Adams // Circulation, 2010; 122:1221–1238.
  2. Bazarin, K. P. The role of reactive oxygen species in adaptation to physical load/ Bazarin K. P. // Sports medicine. – 2014. – № 4. – Р. 7–15.
  3. Balykin, M. V. Changes of blood gas composition and processes of free radical oxidation of lipids in the myocardium during adaptation to physical activity / M. V. Balykin, S. A. Sagidova, A. V. ZHarkov // Russian physiological journal. Sechenov.  T.101. – 2015. – № 9. – P. 1007–1012.
  4. Pereira, F. Interval and continuous exercise training produce similar increases in skeletal muscle and left ventricle microvascular density in rats / F Pereira, R. de Moraes, E.Tibirica, AC Nobrega. // Biomed Rs Int.2013;2013:752817.
  5. Dontsov, V.I. Reactive oxygen species as a system: importance in physiology, and the natural aging / V.I. Dontsov, V.N. Krutko, B.M. Mikael and Ukhanov, S. V. // Proceedings of ISA RAS. – 2006. – №19. – P.50–69.
  6. Lukyanova, L.D. New about the signaling mechanisms of adaptation to hypoxia and their role in system regulation / L.D. Lukyanova, Yu I. Kirova, G.V. Sloan //Pathogenesis. – 2011. – № 3. – P. 4–14.
  7. Savchenko, A.A. Activity Status NAD- and NADP-dependent dehydrogenases in neutrophilic granulocytes in athletes in the dynamics of the training cycle/ A.A. Savchenko, K.P. Bazarin // Journal of Siberian Federal University. Biology. – 2013. – № 6. – P. 151–162.
  8. Chesnokova, N.P. Molecular and cellular mechanisms of induction of free radical oxidation in pathology/ N.P. Chesnokova, E.V. Ponukalina, M.N. Lisenkova // Modern problems of science and education 2006, vol. 6, 21–26.
  9. Achkasov, E.E. The Impact of singlet oxygen on the rate of recovery after the maximum physical work of the players of a young age/ E.E. Achkasov, E.N. Bezuglov, A.E., Ardishvili etc. // Physical therapy and sports medicine. – 2012. – №4(100). – P. 24–28.
  10. Duncker, D.J. Regulation of coronary blood flow during exercise / D.J. Duncker, R.J. Bache // Physiol Rev., 2008.Jul; 88(3):1009–86.
  11. Suzuki, J. Microvascular angioadaptation after endurance training with L-arginin supplementation in rat heart and hindleg muscles / J. Suzuki // Exp Phisiol. 2005 Sep;90(5): 763–71.
  12. Balykin, M.V. changes in the vessels of the microcirculation in different parts of the heart under the action of near-limit physical activity / M. V. Balykin, S. A. Sagitova, // Collection  of new medical technologies «Topical issues of theory and practice of medicine», Tula 2011. – P. 91–93.
  13. Volkova, O.V. Fundamentals of histology with histological techniques / O.V. Volkov, Yu.K. Eletsky – M.: Medicine, 1982. – 304 p.
  14. Shoshenko, K.A. Blood capillaries / K. A. Shoshenko // Ed. ed., M. D., A.D. Slonim. – Acad. med. of Sciences of the USSR: Sib. branch of the Institute of physiology. – Novosibirsk: Science.– Sib. office, 1975. – 374 p.
  15. Katinas, G.S. Method of analyzing quantitative data in Cytology / G.S. Katinas, Yu. z. Polonsky // Cytology. – 1970. – T. 12. – No. 3. – P. 399–403.
  16. Andreeva, L.I. Modification of the method of determination of lipid peroxides in test with thiobarbituric acid. / L.I. Andreeva, L.A. Kozhemyakin, A.A. Kishkun // Lab. business. – 1988. – №11. – P. 86–89.
  17. Vladimirov, Yu.A. Free radicals and antioxidants / Yu.A. Vladimirov // Collection RAMN. – 1998. No. 7. – 43–51.
  18. Karpishchenko, A.I. Medical and laboratory technology and diagnostics / A.I. Karpishchenko. – SPb.: Intermedika, 1999. – P. 27–28.
  19. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein-dye binding // J Analitical Biochemistry 1976; 72: 248.254.