Features of the dynamics of nitric oxide production in the tissues of the heart and liver of rats under restriction motor activity

The aim of this study was to investigate the role of nitric oxide (NO) in the effects arising from the restriction of motor activity (MA), by the analysis of NO in the tissues of the heart and liver of rats, living under distriction of MA. The production of NO was analyzed by electron paramagnetic resonance of the tissues of the heart and liver of rats living under distriction of MA within 30 and 60 days and of the control rats of the corresponding age. Discovered that the quantity of NO produced in the tissues of the heart and liver of rats increased 2-3 times after 30- and 60- day limit of MA. Our founding an increase in the intensity of NO production under restriction of MA allows us to make a conclusion about the presence of close relations between the level of NO in the body with the regime of MA. Since the review of literature data shows that the restriction of MA causes a significant changes in the cardiovascular system, internal organs, blood flow and supply of oxygen to the body, it can be assumed that some of these changes caused by a stationary increase of NO production in the tissues of key activities for organism.

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