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Vol 11 (3) 2023

Article

ACE, PPARA AND PPARG GENETIC MARKERS AS PREDICTORS OF SPORTS PERFORMANCE IN ATHLETES OF DIFFERENT SPORTS (0.27 Mb, pdf) Read
Authors:
Dautova Albina Zufarovna
Semenova Ekaterina Alexandrovna
Zverev Alexey Anatolievich
Nazarenko Andrej Sergeevich
Shamratova Valentina Gusmanovna
Keywords:
genetic selection
polymorphisms
genes
success in sport
Annotation:

The purpose of the research is to study the effect of selection on the distribution of allele frequencies of rs4646994 of the ACE gene, rs4253778 of the PPARA gene, and rs1801282 of the PPARG gene in athletes of various sports.

Materials and research methods. The study involved 250 athletes aged 9 to 41 years with different levels of sports qualifications (academic rowing, athletics, cross-country skiing, swimming). The comparison group consisted of 266 people aged 19 to 25 years not involved in sports.

Research results. It has been established that, regardless of the qualifications of athletes, the rs4646994*I allele prevails among athletes of the aerobic nature of work (children – 68.18%, adults without a category – 66.67%, candidate for master of sport – 66.67% and master of sport, master of sport of international class – 59.09 %). At the same time, in athletes of anaerobic nature of work, the occurrence of the rs4646994*D allele tended to increase with increasing sportsmanship (children - 48.18%, adults without a discharge – 56.58%, candidate for master of sport – 62.5%, master of sport, master of sport of international class – 75%) (χ2=6.14, OR=0.31, p=0.006). The frequency of the rs4253778*G allele prevailed in the stayers compared with the athletes of the anaerobic regime of energy supply (χ2=3.46, OR=0.47, p=0.03) and the comparison group (χ2=4.48, OR=0.49, p=0.017). When assessing the distribution of frequencies of alleles and genotypes of the rs1801282 (PPARG) polymorphism in athletes of different qualifications and specializations, no statistically significant differences were found. 

Conclusion. Thus, the polymorphic variant rs4646994*D (ACE) can be used as one of the selection criteria in speed-strength sports. Alleles rs4646994*I (ACE) and rs4253778*G (PPARA) are favorable for the development of physical quality "endurance". At the same time, with the growth of sports qualification, the distribution of frequencies of alleles rs4646994*I (ACE) and rs4253778*G (PPARA) in athletes of the aerobic energy supply regime did not change. In our study, the rs1801282 polymorphism of the PPARG gene did not show an association with skill growth.

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