Error message

Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in i18n_book_navigation_set_breadcrumb() (line 212 of /home/c/coderteam/

Influence of genetic factors on the maximum oxygen consumption in young rowers of different sports qualification

Бобылев Артем Сергеевич
аспирант кафедры физического воспитания
Образовательная организация: ФГБОУ ВО «Ярославский государственный педагогический университет им. К.Д. Ушинского»
Елькин Юрий Георгиевич
кандидат педагогических наук, подполковник кафедры физической подготовки

Образовательная организация: ФГКВОУ ВО «Ярославское высшее военное училище противовоздушной обороны» Министерства обороны РФ
Мельников Андрей Александрович
доктор биологических наук, профессор, старший преподаватель кафедры физической подготовки
Образовательная организация: ФГКВОУ ВО «Ярославское высшее военное училище противовоздушной обороны» Министерства обороны РФ

Ключевые слова: ACE, ACTN3, NOS3, UCP2, UCP 3, VO2max, rowers

Аннотация: The purpose of the study was to investigate the effects of five polymorphisms: the Alu I/D of the angiotensin converting enzyme gene (ACE), the R577X of alpha-actinin-3 gene (ACTN3), 4b/a of the nitric oxide synthase (NOS3) gene, the Ala55Val of the uncoupling protein 2 gene (UCP2), -55C/T of uncoupling protein 3 gene (UCP3) as well as sports experience on the VO2max in young rowers with different sports qualifications. Materials and methods. We examined six athletes with the candidate for a master of sports qualification (KMS group) and sixteen rowers without sports rang (all athletes aged 15-21 years). The VO2max was determined on a rower ergometer using a gas analyzer, genetic polymorphisms in buccal epithelium DNA or in leukocytes were analyzed by PCR. The sum of the alleles (index Σ) associated with the high athletic result in rowing was calculated as Σ= ACE I+ACTN3 R+ NOS3 b + UCP2 Val + UCP3 T. Results. It was found that the KMS rowers had higher parameters than the athletes without sports rang: VO2max (p <0.001), athletic experience (p<0.001), as well as the frequency of the ACE I allele (p = 0.035) and Σ (p = 0.002). Differences in the frequency of the genotypes of polymorphisms ACTN3 R577X, NOS3 4b/a, UCP2 Ala55Val and UCP3 -55C/T between groups were not revealed. VO2max correlated with Σ (р = 0,020) and sports experience (р = 0,001). The conclusion. The increased level of VO2max in rowers with qualifications of KMS is due to the interaction of the genetic predisposition as indicated to more alleles in the genes (ACE I, ACTN3 R, NOS3 b, UCP2 Val and UCP3 T), associated with different endurance components, and longer periods of rowing.

Список литературы:

  1. Ahmetov, I.I. The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes / I.I. Ahmetov, A.G. Williams, D.V. Popov, E.V. Lyubaeva, A.M. Hakimullina et al // Hum. Genet. – 2009. – V. 126. – № 6. – P. 751-761.
  2. Ahmetov, I.I. The Use of Molecular Genetic Methods for Prognosis of Aerobic and Anaerobic Performance in Athletes. / I.I. Ahmetov, D.V. Popov, I.V. Astratenkova, A.M. Druzhevskaya, S.S. Missina et al // Human Physiology. – 2008. – V. 34. – № 3. – P. 338-343.
  3. Bouchard, C. Familial aggregation of VO2 max response to exercise training: results from the HERITAGE family study / C. Bouchard, P. An, T. Rice, J.S. Skinner et al // J. Appl. Physiol. – 1999. – V. 87. – P. 1003-1008.
  4. Busiello, R.A. Mitochondrial uncoupling proteins and energy metabolism / R.A. Busiello, S. Savarese, A. Lombardi // Front. Physiol. – 2015. – V. 6. – P. 36. doi:10.3389/fphys.2015.00036
  5. Gayagay, G. Elite endurance athletes and the ACE I allele – The role of genes in athletic performance / G. Gayagay, B. Yu, B. Hambly, T. Boston, A. Hahn, D.S. Celermajer // Hum. Genet. – 1998. – V.103. – P. 48-50.
  6. Guazzi, M. Angiotensin-converting enzyme inhibition facilitates alveolar-capillary gas transfer and improves ventilation-perfusion coupling in patients with left ventricular dysfunction / M. Guazzi, G. Melzi, G.C. Marenzi, P. Agostoni // Clin. Pharmacol. Ther. – 1999. – V. 65. – № 3. – P. 319-327.
  7. Hagerman, F.C. Applied physiology of rowing / F.C. Hagerman // Sports Med. – 1984. – V. 1. – № 4. – P. 303-326.
  8. Schrauwen, P. A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians / P. Schrauwen, J. Xia, K. Walder, S. Snitker, E. Ravussin // Int. J. Obes. Relat. Metab. Disord. – 1999. – V. 23. – № 12. – P. 1242-1245.
  9. Williams, A.G. Genetic testing in exercise and sport – have direct-to-consumer genetic tests come of age / A.G. Williams, S.M. Heffemen, S.H. Day // Science and Sport: Current Trends. – 2014. – V. 2. – № 1. – P. 3-10.
  10. Woods, D.R. The ACE I/D Polymorphism and Human Physical Performance / D.R. Woods, S.E. Humphries, H.E. Montgomery // Trends Endocrinol. Metabol. – 2000. – V. 11. – P. 416-420.

Показать полный текст